Hi kh,
Thanks for your post.

I am not sure I understand your requirement very well. Do you want to show
the context menu based on different location the user right clicked the
mouse button? For example, when you right clicked row header or second
column, you want to display certain context menu; while for first column,
you want to display another context menu. If I misunderstand you, please
feel free to tell me, thanks!

For this, we can handle DataGridView.MouseDown event, then use
DataGridView.HitTest method to determine which cell the mouse pointer is
in. Then associate different context menu with
DataGridView.ContextMenuStrip property. Sample code like this:

private void Form1_Load(object sender, EventArgs e)

{
   DataTable dt = new DataTable();
   dt.Columns.Add(new DataColumn("column1", typeof(int)));
   dt.Columns.Add(new DataColumn("column2", typeof(string)));
   for (int i = 0; i < 5; i++)
   {
       DataRow dr = dt.NewRow();
       dr["column1"] = i;
       dr["column2"] = "item" + i.ToString();
       dt.Rows.Add(dr);
   }
   this.dataGridView1.DataSource = dt;
}

private void dataGridView1_MouseDown(object sender, MouseEventArgs e)
{
   DataGridView.HitTestInfo hti=this.dataGridView1.HitTest(e.X, e.Y);
   if (hti.ColumnIndex == -1 || hti.ColumnIndex == 1)
   {
       this.dataGridView1.ContextMenuStrip = this.contextMenuStrip2;
   }
   else
   {
       this.dataGridView1.ContextMenuStrip = this.contextMenuStrip1;
   }

}

Note: in the code snippet, I suppose that we have created 2
contextMenuStrips: contextMenuStrip1 and contextMenuStrip2.
It works well on my side. Hope it helps.

Best regards,
Terry Fei

Microsoft Online Partner Support