If you mean to start MS Access from your app and then do something in the
Access, then you would use ActiveX automation through COM Interop.

You set reference to Access Object library (better yet, use PIA provided by
MS, if the Access version is 2002 or later). and then use code like this:

Dim accApp As Access.Applicrion
accApp=New Access.Application
accApp.Visible=True

'Do something with accApp. You need to study Access Object Nodel to see what
you can do

accApp.Quit

However, if you only need to do some data (in the mdb file) manipulating,
you may not need to automate Access. That is the point for you to write a
stand-alone app in VB.NET. I'd rather write a Access app if I have to use
functionality only available in Access, since Access installation is
required for automation, anyway.