Sure, open the Processes dialog, select inetinfo.exe (or whatever your IIS process is called), on the next dialog select Script (only).
Open script files, set breakpoints with F9, enjoy!
This should work with VB-only IDE I think.

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> From: "Bruce Wayne" <news@nospam.achren.org>
> Subject: ASP 3 Debugging and Tracing in VB.Net
[quoted text clipped - 24 lines]
> PS. Just found this http://www.script-debugger.com/ but haven't got it
> working yet either. Cant attach to a process.