Hi Mike,

Thank you for posting here.

I noticed that you have posted the same question in our
microsoft.public.dotnet.framework newsgroup, which I have already
responded. So please check my answer there and if you need any further
assistance on this particular issue, please reply to me in that thread so I
can follow up with you in time.

For your convenience, I have included my reply as follows.

====================================================
Based on my understanding, you have a ClickOnce deployed application. When
a new version is installed and the application is run, some controls on the
main form are disabled. If you exit the application and then restart , all
works fine. If I'm off base, please feel free to correct me.

In theory, when an application is updated on a client machine via
ClickOnce, the application files of the new version are downloaded to the
client pc to replace the old files. This action won't disable the controls
of the application.

I have also searched KB on Microsoft web site, but unfortunately I didn't
find an article discussing about this problem.

Could you please tell me how you update the applicaiton via ClickOnce? Do
you use the default behaviour of ClickOnce (Project designer| Publish |
Updates, select the checkbox before the item "The application should check
for updates") , or program custom upgrade behavior with the classses in
System.Deployment.Application namespace?

If you update the application with custom upgrade behavior, have you
disabled some controls at the beginning of the upgrade, but forgotten to
enable them after the upgrade is finished?

=====================================================

Thank you and have a nice day!

Sincerely,
Linda Liu
Microsoft Online Community Support

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ClickOnce is able for multiple versions deployment but I do not think is
appropriate for updating the app. I would suggest uninstall before Click the
ClickOnce is better.

chanmm