You're going to have to describe what *does* happen... any messages?

I've used ClickOnce many times, so I may recognise any common errors -
but first questions:
* do the users have .NET (correct version) installed? (esp. if linking
to the .application, not the .html)
* have you signed the deployment with a trusted cert

I have seen some very rare, freaky "exe appears (task list) and then
simply evaporates and does nothing without any error trace" (even with
all click-once, fusion, etc debugging enabled), but we're talking 1-
in-1000 figures, here.

Marc