Hi,
you can try code something like this below:
DataTable dt = new DataTable();
            DataColumn col1 = new DataColumn();
            DataColumn col2 = new DataColumn();
            col1.ColumnName = "Name";
            col2.ColumnName = "Age";

            col1.DataType = typeof(System.String);
            col2.DataType = typeof(System.Int32);
            col2.ColumnMapping = MappingType.Hidden;
            dt.Columns.Add(col1);
            dt.Columns.Add(col2);

            DataRow row1 = dt.NewRow();

            row1["Name"] = "manih bafna";

            dt.Rows.Add(row1);
            dataGrid1.DataSource = dt;

You could copy the DataTable in its entirety, and then remove the
columns you don't need.
For example:

DataTable newDT = oldDT.Copy();
newDT.Columns.Remove("B");
newDT.Columns.Remove("D");

someObj.someMethod(newDT);

Chris.