I'd recommend that you do whatever makes you the most productive.  The right
answer is different for everyone.

Paul T.

It makes no difference unless you think you might need unsafe code (pretty
rare for most).

-Chris

Hi chook,
the .net framework was designed to be language independant to allow adoption
by folks that need "productivity" over learning a new language. Everything
you build will compile to a commond MSIL (assembly-like) code that is
"creation" language independant or abstract. The MSIL from the VB compiler
and the C# compiler for the mobile device are nearly and operationally
identical and should not be a reason for choosing a language outside your
familiarity. Be comfortable - go forth and Produce, in whatever language
makes you heart sing. You will find ample examples to cover your questions in
any of the TOP 4 (.net C++, C#, VB.net, or J#) - and through the study of the
types and members that they exploit, you can translate what isnt in your
language of choice.