There would be some marginal difference, but you are unlikely to notice it.
Using strongly typed DataSets make your coding cleaner, safer and more
readable

Napo,

In the use of the Strongly Typed Dataset is a use that is seldom done with
the typed dataset.

That is referencing the columns by the column property instead of string and
index.

That makes de Strongly Typed Dataset by testing mostly slightly faster. As
OHM says is the gain of time so few, that any thinking about this cost more.

Just my idea

Cor

It depends. There's a lot of debate about this. Strongly typed datasets have
a lot of advantages with respect to typing, but as such, have a lot of
try/catch blocks and exception handling that can slow them down. However in
all likelihood, you're going to have to write the same stuff yourself so it
really depends.  It's not an apples to apples comparison until you factor in
the exception handling.