Sure, look at the TcpClient class.
Yes, the destination computer should have a sort of driver that takes care
about serving client requests.

Signature
Eliyahu Goldin,
Software Developer
Microsoft MVP [ASP.NET]
http://msmvps.com/blogs/egoldin
http://usableasp.net
> Hi, can asp.net (2.0 C# VS 2005) send some kind of information via TCP/IP
> to a computer that will be on the local network?
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>
> Thanks!