It's an Enterprise CA, in contact with active directory.  But web based
certificate requests fail with the following error reported in Internet
Explorer (6.0, security set to medium):

Failed to create 'CertificateAuthority.Request' object.

When I look in various logs, the only relevant entry I can find
is this in the Applications Log:

Source: Active Server Pages
Category: None
Event ID: 5

and then this description

Error: The Template Persistent Cache initialization failed for
Application Pool 'DefaultAppPool' because of the following
error: Could not create a Disk Cache Sub-directory for the
Application Pool. The data may have additional error codes..

There are no additional codes.  There's plenty of room on the hard
drive, plenty of room in memory.  I looked up the error on MS's site, and
found only one article about
it, where they identified the cause as the IIS_WPG group losing
its permissions on three directories.  I checked those
directories and all permissions were as they should be.

Anyone have any ideas?

Thanks in advance,

Mike