This is a BIG question , in that you can configure a DataGrid in so many
different ways!  The right anwser depends on the way you are using the
DataGrid.

I almost always solve such questions in the core SQL itself, by writing the
SQL to match the columns required.  Less coding is necessary to bind such
data to a DataGrid object this way, and just about any SQL you write will
work.

If you are creating the DataGrid in code, of if dynamic SQL is not an
option, then leverage static SQL by adding only the required columns to your
DataGrid.  There are tons of examples of how to do this on the web.   Here
are two starters:
http://odetocode.com/Articles/218.aspx
http://www.c-sharpcorner.com/Database/PlayingWithDataGridTA.asp

Good luck,
Curt