It may not be "the best way", but as far as I know it's "the only way".

cHTML, xHTML, WML, HTML (which are the Markups supported by MMIT) all have
the same syntaxes for defining tables, although some WML devices don't
render tables, but they are very few (and very old too!!!)

so the solution I came up with, was constructing a simple table around the
controls like this:
<table>
          <tbody>
                  <tr>
                      <td><Mobile:Command
runat="server">Command</Mobile:Command>
                           </td>
                       <td><Mobile:Command
runat="server">Command</Mobile:Command>
                       </td>
                   </tr>
               </tbody>
           </table>

hope it work for you, if not, let me know the specific case so we can figure
out something!!

--

Juan David Gomez A.
Microsoft Certified Professional
Analista de Desarrollo - PSL S.A.
Web and Wireless Banking
Medellin - Colombia